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This study was conducted to determine the relationship between the sufentanil concentrations achieved by sublingual and oral administration and the subsequent D2 receptor occupancy in nine healthy subjects. R(+)- and S(-)-sufentanil were administered sublingually at doses of 3 microg and 6 microg, respectively, followed 1 h later by oral administration of 3 microg of R(+) and S(-)-sufentanil. Blood samples were collected at regular intervals during and after the study for determination of the levels of sufentanil and its metabolites. Urine samples were collected as early as 4 h post-administration. Sublingual and oral administration of sufentanil resulted in comparable levels of sufentanil and des-isosufentanil as well as des-tyrosine-sufentanil in blood. Sulfoxide-sufentanil was barely detected in blood. There was no significant difference in the D2 receptor occupancy at sufentanil concentrations of 1.5 to 7 times that found in blood after sublingual versus oral administration. There was also no significant difference in the D2 receptor occupancy of R(+) and S(-)-sufentanil administered sublingually versus orally. Taken together, these findings indicate that, in addition to the rapid absorption of sufentanil through the oral mucosa, the lack of active metabolites limits the systemic effects of oral sufentanil. The modest sufentanil concentrations achieved in oral saliva and blood are not associated with a greater D2 receptor occupancy.1. Field of the Invention
The present invention generally relates to an electric submersible pump and, more particularly, to an electric submersible pump that is capable of being installed in a deep well and, at the same time, capable of discharging debris of a pump element or working components of a pump.
2. Description of the Related Art
U.S. Pat. No. 6,139,305 discloses an electric submersible pump in the prior art. The electric submersible pump includes a casing and a rotary part which is disposed in the casing. The rotary part is rotated by a driving
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